Secondary structural complementarity between DNA and proteins.
نویسندگان
چکیده
A model for the complex between double-stranded DNA and a beta-ribbon (a two-stranded antiparallel beta-sheet) of proteins is proposed as one of the possible modes of structural recognition between DNA and proteins. In this model, the contact occurs on the narrow groove of DNA, and the symmetry elements as well as the repeat distances of DNA and the beta-ribbon coincide, thus providing favorable complementary contacts.
منابع مشابه
Designing and Development of a DNA Vaccine Based On Structural Proteins of Hepatitis C Virus
Background: Hepatitis C virus (HCV) infection is one of the most prevalent infectious diseases responsible for high morbidity and mortality worldwide. Therefore, designing new and effective therapeutics is of great importance. The aim of the current study was to construct a DNA vaccine containing structural proteins of HCV and evaluation of its expression in a eukaryot...
متن کاملAn efficient and simple CTAB based method for total genomic DNA isolation from low amounts of aquatic plants leaves with a high level of secondary metabolites
An efficient DNA isolation protocol specifically modified to get pure quality DNA required for molecular studieshas been reported in this paper. Some aquatic plants (Potamogeton spp., Ceratophyllum demersum and Myriophyllum spicatum) were used for the study. The protocol developed will be useful in getting high and pure DNA. Instead of using the available DNA extraction kits, this protocol can ...
متن کاملSPECTROSCOPIC EVALUATION OF THE INTERACTION OF A TETRAZOLE DERIVATIVE SYNTHESIZED BY SEMI-GREEN METHOD WITH CALF THYMUS DNA AND BOVINE SERUM PROTEIN
Background & Aims: In recent decades, the application of tetrazole structures in various fields of medicine and industry has become very important, because they can cause structural and thus functional changes in the proteins. In this article, the effect of a new tetrazole derivative on calf thymus DNA (Ct-DNA) as well as on bovine serum albumin protein (BSA) in the solution was determined usin...
متن کاملEvolution of the genetic code: the nonsense, antisense, and antinonsense codes make no sense.
According to the molecular recognition theory, the complementarity of the sense and nonsense DNA strands is reflected in a complementarity of polypeptides and the corresponding nonsense polypeptides. A comparison of the sense and nonsense code matrices, and of the antisense and antinonsense code matrices, either by visual inspection or by comparing the corresponding hydrophobicity matrices (e.g...
متن کاملR - Looping and Structural Gene Identification
The advent of recombinant DNA technology has made possible studies on the organization and expression of eukaryotic genes, which were previously restricted to prokaryotic and viral genes. In large measure, these studies exploit and are dependent upon the availability-through recombinant DNA molecules--of large amounts of individual eukaryotic DNA sequences. They are also dependent upon an accur...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 74 4 شماره
صفحات -
تاریخ انتشار 1977